Literature summary for 3.4.17.23 extracted from

Wang, Y.; Fan, Y.; Huang, Y.; Du, T.; Liu, Z.; Huang, D.; Wang, Y.; Wang, N.; Zhang, P.
TRIM28 regulates SARS-CoV-2 cell entry by targeting ACE2 (2021), Cell. Signal., 85, 110064 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9BYF1	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
ACE2	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	knockdown of TRIM28 induces enzyme (ACE2) expression. TRIM28 knockdown enhances interferon-gamma (IFN-gamma)-induced ACE2 expression through a mechanism involving upregulating IFN-gamma receptor 2 (IFNGR2) in both A549 and PAEpiCs. The upregulated ACE2 induced by TRIM28 knockdown and co-culture of NK cells is partially reversed by dexamethasone in A-549 cells. TRIM28 is a novel regulator of ACE2 expression and SARS-CoV-2 cell entry	up

General Information

General Information	Comment	Organism
physiological function	severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease, it binds to angiotensin-converting enzyme 2 (ACE2) to enter into human cells. The expression level of ACE2 potentially determines the susceptibility and severity of COVID-19	Homo sapiens

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Release 2023.1 (January 2023)